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Manzamine A hydrochloride inhibits specifically GSK-3β and CDK-5 with IC50s of 10.2 μM and 1.5 μM, respectively. Manzamine A hydrochloride targets vacuolar ATPases and inhibits autophagy in pancreatic cancer cells. Manzamine A hydrochloride also shows potent activity against HSV-1.
| Molecular Weight | 585.22 |
| Formula | C36H45ClN4O |
| CAS Number | 104264-80-4 |
| Form | Solid |
| Solubility (25°C) | DMSO 5 mg/mL (ultrasonic) |
| Storage | 4°C, protect from light, dry, sealed |
[2] Iain Coldham et al. J Org Chem. Synthesis of the ABC ring system of manzamine A
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