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LY3020371 

Cat. No. M28288

All AbMole products are for research use only, cannot be used for human consumption.

LY3020371  Structure

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Quality Control & Documentation
Biological Activity

LY3020371 is a potent and selective antagonist of glutamate (mGlu) 2/3 receptor, with Kis of 5.26 and 2.50 nM for hmGluR2 and hmGluR3, respectively. LY3020371 can be used for the research of depression.

Chemical Information
Molecular Weight 359.35
Formula C15H15F2NO5S
CAS Number 1377615-75-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Nicola Hanley, et al. Sleep. Pharmacological Modulation of Sleep Homeostasis in Rat: Novel Effects of an mGluR2/3 Antagonist

[2] J M Witkin, et al. Pharmacol Biochem Behav. Preclinical predictors that the orthosteric mGlu2/3 receptor antagonist LY3020371 will not engender ketamine-associated neurotoxic, motor, cognitive, subjective, or abuse-liability-related effects

[3] J M Witkin, et al. J Pharmacol Exp Ther. Comparative Effects of LY3020371, a Potent and Selective Metabotropic Glutamate (mGlu) 2/3 Receptor Antagonist, and Ketamine, a Noncompetitive N-Methyl-d-Aspartate Receptor Antagonist in Rodents: Evidence Supporting the Use of mGlu2/3 Antagonists, for the䲧瘀Ỵ瘁㧀痿羹皘

[4] Mark D Chappell, et al. J Med Chem. Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity

[5] Jeffrey M Witkin, et al. Neuropharmacology. In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu2/3 receptor antagonist

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Keywords: LY3020371  supplier, GluR, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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