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LY2584702 Tosylate

Cat. No. M4864
LY2584702 Tosylate Structure
Synonym:

LY2584702

Size Price Availability Quantity
10mM*1mL in DMSO USD 120  USD120 In stock
5mg USD 90  USD90 In stock
10mg USD 130  USD130 In stock
50mg USD 380  USD380 In stock
100mg USD 580  USD580 In stock
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Quality Control & Documentation
Biological Activity

LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus.

Chemical Information
Molecular Weight 617.62
Formula C28H27F4N7O3S
CAS Number 1082949-68-5
Solubility (25°C) DMSO 7 mg/mL
Water <1 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Tolcher A, et.al Eur J Cancer. A phase I trial of LY2584702 tosylate, a p70 S6 kinase inhibitor, in patients with advanced solid tumours.

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Keywords: LY2584702 Tosylate, LY2584702 supplier, S6 Kinase, inhibitors, activators


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