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LV-320 is a potent and uncompetitive ATG4B inhibitor with an IC50 of 24.5 µM and a Kd of 16 µM. LV-320 inhibits ATG4B enzymatic activity, blocks autophagic flux in cells, and is stable, non-toxic and active in vivo.
| Molecular Weight | 520.11 |
| Formula | C29H26ClNO2S2 |
| CAS Number | 2449093-46-1 |
| Form | Solid |
| Solubility (25°C) | DMSO 135 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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