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Luspatercept

Cat. No. M24634
Luspatercept Structure
Synonym:

ACE-536; luspatercept-aamt

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Quality Control & Documentation
Biological Activity

Luspatercept (ACE-536) is a first-in-class recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia.

Chemical Information
CAS Number 1373715-00-4
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] No authors listed. Luspatercept

[2] No authors listed. Luspatercept

[3] Maria Domenica Cappellini, et al. Blood Adv. The use of luspatercept for thalassemia in adults

[4] M Domenica Cappellini, et al. N Engl J Med. A Phase 3 Trial of Luspatercept in Patients with Transfusion-Dependent β-Thalassemia

[5] Pierre Fenaux, et al. N Engl J Med. Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes

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  Catalog
Abmole Inhibitor Catalog




Keywords: Luspatercept, ACE-536; luspatercept-aamt supplier, TGF-beta/Smad, inhibitors, activators


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