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Luspatercept

Cat. No. M24634

All AbMole products are for research use only, cannot be used for human consumption.

Luspatercept Structure
Synonym:

ACE-536; luspatercept-aamt

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Biological Activity

Luspatercept (ACE-536) is a first-in-class recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia.

Chemical Information
CAS Number 1373715-00-4
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] No authors listed. Luspatercept

[2] No authors listed. Luspatercept

[3] Maria Domenica Cappellini, et al. Blood Adv. The use of luspatercept for thalassemia in adults

[4] M Domenica Cappellini, et al. N Engl J Med. A Phase 3 Trial of Luspatercept in Patients with Transfusion-Dependent β-Thalassemia

[5] Pierre Fenaux, et al. N Engl J Med. Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes

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  Catalog
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Keywords: Luspatercept, ACE-536; luspatercept-aamt supplier, TGF-beta/Smad, inhibitors, activators

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