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LQZ-7I is a novel selectively inhibitor of survivin dimerization with IC50s of 4.8 µM and 3.1 µM in prostate cancer cell lines PC-3 and C4-2, respectively. LQZ-7I orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors.
| Molecular Weight | 348.35 |
| Formula | C₂₀H₁₄F₂N₄ |
| CAS Number | 195822-23-2 |
| Solubility (25°C) | DMSO 70 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Survivin Products |
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| GDP366
GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. |
| YM155
YM155 (Sepantronium Bromide) is a novel small molecule that suppresses transactivation of survivin through direct binding to its promoter. |
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