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YM155 (Sepantronium bromide) is a novel small molecule survivin suppressant with an IC50 of 0.54 nM for the inhibition of survivin promoter activity. YM155 also completely inhibited the growth of orthotopically xenografted PC-3 tumors. YM155 suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nmol/L. It selectively suppresses expression of survivin and induces apoptosis in p53-deficient cancer cells in vitro at 10 nM. YM155 is highly distributed to tumors and at concentrations approximately 20-fold higher than those in plasma. YM155 exerts anti-tumor effects in various in vivo cancer models, including prostate, pancreatic, and lung cancer.
BMC Biol. 2021 May 20;19(1):108.
Very long intergenic non-coding (vlinc) RNAs directly regulate multiple genes in cis and trans
YM155 purchased from AbMole
Nat Commun. 2019 Dec 20;10(1):5799.
Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells.
YM155 purchased from AbMole
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Source | J Transl Med (2018). Figure 2. YM155 |
| Method | Cell viability assay | |
| Cell Lines | U251 and U87 cells | |
| Concentrations | 5 nM | |
| Incubation Time | 48 h | |
| Results | Cell viability decreased significantly in cells treated with both radiation and YM155 (5 nM) compared to radiation alone |
| Molecular Weight | 443.29 |
| Formula | C20H19BrN4O3 |
| CAS Number | 781661-94-7 |
| Solubility (25°C) | DMSO 45 mg/mL Water 80 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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| GDP366
GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. |
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Products are for research use only. Not for human use. We do not sell to patients.
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