About 8 results found for searched term "Survivin" (0.241 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2342 | YM155 | Survivin |
| Sepantronium bromide | ||
| YM155 (Sepantronium Bromide) is a novel small molecule that suppresses transactivation of survivin through direct binding to its promoter. | ||
| M10394 | FL118 | p53 |
| FL-118; CAS# 151636-76-9 | ||
| FL118 is an inhibitor of human survivin expression, activating tumor suppressor p53 as a novel MOA in p53 wild-type cancer cells. | ||
| M11166 | Shepherdin (79-87) | HSP |
| Shepherdin (79-87) is a 79 to 87 amino acid fragment of Shepherdin. Shepherdin is a peptide-mimetic antagonist of Hsp90-Survivin complex. Has antitumor activity. | ||
| M13557 | GDP366 | Survivin |
| GDP366, a dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. | ||
| M20839 | LQZ-7I | Survivin |
| LQZ-7I is a novel selectively inhibitor of survivin dimerization with IC50s of 4.8 µM and 3.1 µM in prostate cancer cell lines PC-3 and C4-2, respectively. LQZ-7I orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors. | ||
| M29240 | DK419 | Wnt/beta-catenin |
| DK419 is a potent and orally active Wnt/β-catenin signaling inhibitor, with an IC50 of 0.19 μM. DK419 reduces protein lelvels of Axin2, β-catenin, c-Myc, Cyclin D1 and Survivin and induces production of pAMPK. | ||
| M30259 | (E)-Ferulic acid | Wnt/beta-catenin |
| (E)-Coniferic acid | ||
| (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299. | ||
| M54797 | Isolinderalactone | VEGFR/PDGFR |
| Isolinderalactone suppresses human glioblastoma growth and angiogenic activity through the inhibition of VEGFR2 activation in endothelial cells. Isolinderalactone suppressed the expression of B-cell lymphoma 2 (BCL-2), as well as of survivin and X-linked inhibitor of apoptosis protein (XIAP). | ||
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