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Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase.
| Molecular Weight | 455.42 |
| Formula | C26H28Cl2N2O |
| CAS Number | 26786-32-3 |
| Solubility (25°C) | DMSO 45 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[2] J R Herdman et al. J Affect Disord. Effect of lofepramine on 5-HT function and sleep
[5] F Reid et al. Pharmacopsychiatry. Lofepramine overdosage
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