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Lipoteichoic acid

Cat. No. M9917
Lipoteichoic acid Structure
Synonym:

LTA

Size Price Availability Quantity
5mg USD 850  USD850 In stock
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Quality Control & Documentation
Biological Activity

Lipoteichoic acid (LTA) is a complex component of cell walls of Gram-positive bacteria that are involved in a wide range of cell processes such as the stimulation of immune responses and cell signaling pathways, also used as adjuvant. Lipoteichoic acid (LTA) is a pathogen-associated molecular-patterns (PAMP) recognized by Toll-like receptor 2 (TLR2), This recognition leads to the activation of NF-kB.

Chemical Information
CAS Number 56411-57-5
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Arie J Hoogendijk, et al. J Biol Chem. AMP-activated protein kinase activation by 5-aminoimidazole-4-carbox-amide-1-β-D-ribofuranoside (AICAR) reduces lipoteichoic acid-induced lung inflammation

[2] Christoph Schmolzer, et al. Carbohydr Res. Gram scale de novo synthesis of 2,4-diacetamido-2,4,6-trideoxy-D-galactose

[3] Ingmar J J Claes, et al. Microb Cell Fact. Lipoteichoic acid is an important microbe-associated molecular pattern of Lactobacillus rhamnosus GG

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