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Cat. No. M21400
LHVS  Structure
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Quality Control & Documentation
Biological Activity

LHVS is a potent, non-selective, irreversible, cell-permeable inhibitor of cysteine protease and cathepsin. lHVS reduces actin ring formation. lHVS inhibits T. gondii invasion with an IC50 of 10 μM.

Chemical Information
Molecular Weight 527.68
Formula C28H37N3O5S
CAS Number 170111-28-1
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Melanie Key, et al. J Vis Exp. Determination of Chemical Inhibitor Efficiency against Intracellular Toxoplasma Gondii Growth Using a Luciferase-Based Growth Assay

[2] Tippawan Liabsuetrakul, et al. Health Serv Res Manag Epidemiol. Improvement of Early Antenatal Care Initiation: The Effects of Training Local Health Volunteers in the Community

[3] Subhajit Sengupta, et al. Nucleic Acids Res. Ultra-fast local-haplotype variant calling using paired-end DNA-sequencing data reveals somatic mosaicism in tumor and normal blood samples

[4] Michele J Upvall, et al. Health Care Women Int. Behind the mud walls: the role and practice of lady health visitors in Pakistan

[5] J Hezekiah. Health Care Women Int. The pioneers of rural Pakistan: the Lady Health Visitors

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Keywords: LHVS supplier, Cathepsin, inhibitors, activators

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