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Leonurine is an alkaloid isolated from Herba leonuri, with anti-oxidative and anti-inflammatory. Leonurine (0, 5, 10, 20, 40, 80 µM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ.
| Molecular Weight | 311.33 |
| Formula | C14H21N3O5 |
| CAS Number | 24697-74-3 |
| Solubility (25°C) | DMSO 30 mg/mL (ultrasonic and adjust pH to 2 with HCl) |
| Storage | 2-8°C, dry, sealed |
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