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LEO 39652

Cat. No. M21314

All AbMole products are for research use only, cannot be used for human consumption.

LEO 39652 Structure
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Biological Activity

LEO 39652 is a dual-soft PDE4 inhibitor with IC50 values of 1.2 nM for PDE4A, 1.2 nM for PDE4B, 3.0 nM for PDE4C, and 3.8 nM for PDE4D. LEO 39652 also inhibits TNF-α with an IC50 value of 6.0 nM. LEO 39652 is used in topical studies of atopic dermatitis.

Chemical Information
Molecular Weight 421.45
Formula C23H23N3O5
CAS Number 1445656-91-6
Solubility (25°C) DMSO : 25 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Stefan Eirefelt, et al. Pharm Res. Evaluating Dermal Pharmacokinetics and Pharmacodymanic Effect of Soft Topical PDE4 Inhibitors: Open Flow Microperfusion and Skin Biopsies

[2] Jens Larsen, et al. J Med Chem. Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3 H-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5- a]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel "Dual-Soft" PDE4 Inhibitor for Topical Treatment of Atopic Dermatitis

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Keywords: LEO 39652 supplier, PDE, inhibitors, activators

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