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LEO 134310

Cat. No. M21063

All AbMole products are for research use only, cannot be used for human consumption.

LEO 134310 Structure

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Quality Control & Documentation
Biological Activity

LEO 134310 is a non-steroidal, selective glucocorticoid receptor (GR) agonist that is being studied in the first phase of plaque psoriasis.LEO 134310 has shown high affinity (EC50 of 14 nM) in GR binding assays.LEO 134310 can be used in dermatological conditions.

Chemical Information
Molecular Weight 604.69
Formula C34H40N2O8
CAS Number 2089130-74-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Stefan Eirefelt, et al. Sci Rep. Characterization of a novel non-steroidal glucocorticoid receptor agonist optimized for topical treatment

[2] Kevin N Dack, et al. Bioorg Med Chem Lett. Topical 'dual-soft' glucocorticoid receptor agonist for dermatology

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