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Laulimalide

Cat. No. M10844

All AbMole products are for research use only, cannot be used for human consumption.

Laulimalide Structure

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Quality Control & Documentation
Biological Activity

Laulimalide is an Microtubule stabilizing agent. Laulimalide is a potent inhibitor of cellular proliferation in cancer cell lines (IC50 reported to be 3-30 nM, dependent on cell line used). Laulimalide causes cells to arrest in the prometaphase of the cell cycle, prevents formation of bipolar spindle and increases kinetochore tension in preformed spindles.

Chemical Information
Molecular Weight 514.65
Formula C30H42O7
CAS Number 115268-43-4
Solubility (25°C) DMSO ~10 mg/mL
Storage -20°C, sealed
References

[1] Cassandra D M Churchill, et al. Chem Biol Drug Des. The Unique Binding Mode of Laulimalide to Two Tubulin Protofilaments

[2] Megha Bajaj, et al. PLoS One. Laulimalide induces dose-dependent modulation of microtubule behaviour in the C. elegans embryo

[3] Melissa M Gajewski, et al. Pharm Res. Peloruside, laulimalide, and noscapine interactions with beta-tubulin

[4] Erin A Clark, et al. Mol Pharm. Laulimalide and synthetic laulimalide analogues are synergistic with paclitaxel and 2-methoxyestradiol

[5] S L Mooberry, et al. Cancer Res. Laulimalide and isolaulimalide, new paclitaxel-like microtubule-stabilizing agents

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Keywords: Laulimalide supplier, Microtubule, inhibitors, activators

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