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L-Thyroxine

Cat. No. M5758

All AbMole products are for research use only, cannot be used for human consumption.

L-Thyroxine Structure
Synonym:

NSC 36397

Size Price Availability Quantity
100mg USD 30  USD30 In stock
500mg USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

L-Thyroxine is a synthetic form of thyroxine and a hormone replacement compound. L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. In rats fed 12 weeks with the iodine-free diet, a significant decrease in the levels of both Triiodothyronine and L-Thyroxine is observed when compared to the control group fed with standard diet (p<0.001). In the group treated with low doses of L-Thyroxine, an increase in L-Thyroxine levels is observed (p=0.02) while Triiodothyronine levels remain virtually similar to the control group (p=0.19).

Chemical Information
Molecular Weight 776.87
Formula C15H11I4NO4
CAS Number 51-48-9
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Stasiolek M, et al. Folia Histochem Cytobiol. Effect of L-thyroxine treatment on peripheral blood dendritic cell subpopulations in patients with Hashimoto's thyroiditis.

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Keywords: L-Thyroxine, NSC 36397 supplier, Metabolite/Endogenous Metabolite, inhibitors, activators

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