L-Thyroxine sodium (Levothyroxine sodium) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
Molecular Weight | 798.85 |
CAS Number | 55-03-8 |
Solubility (25°C) | DMSO 62.5 mg/mL Water 14 mg/mL (ultrasonic and adjust pH to 12 with NaOH) |
Storage | 2-8°C, protect from light, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[2] Andrzej Katrusiak, et al. Thyroxine revisited
[3] P R Kerndt, et al. Fasting: the history, pathophysiology and complications
Related Animal Modeling Products |
---|
Keyhole limpet hemocyanin (from prawns, 98%)
Keyhole limpet hemocyanin is a copper protein that binds reversibly to oxygen, and it is lime green when oxidized and white when reduced. Keyhole limpet hemocyanin has oxygen-carrying function, antiviral activity, antibacterial activity, and coagulation function. |
Astragalus Polysacharin (70%)
Astragalus Polysacharin is a natural product from Astragalus membranaeus, used as adjuvant, attenuates TNF-α-induced insulin resistance by suppressing miR-721 and activating PPAR-γ and PI3K/Akt in 3T3-L1 adipocytes. |
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat
Myelin Oligodendrocyte Glycoprotein Peptide (35-55), mouse, rat (MOG (35-55)) is a minor component of CNS myelin. |
PLP (139-151)
PLP (139-151) is amino acid residue 139 to 151 of myelin proteolipid protein (PLP) used to induce experimental autoimmune encephalomyelitis (EAE). |
G6PI 325-339 (human)
G6PI 325-339 (human) is an efficient inducer of arthritis in B10.Q mice. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.