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L-Methionine sulfoximine

Cat. No. M9869
L-Methionine sulfoximine Structure
Size Price Availability Quantity
1g USD 360  USD360 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

L-Methionine sulfoximine is a potent inhibitor of glutamine sythetase (GS) activity, used as a selection agent for plasmid integration in Chinese hamster ovary (CHO) and other mammalian cell lines. L-Methionine sulfoximine (MSX) enhances NH3 production in seedling leaves wheat, barley, corn and sorghum plants by inhibiting glutamine synthetase (GS) activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 180.23
Formula C5H12N2O3S
CAS Number 15985-39-4
Purity >99%
Solubility Water 38 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Davina Chai, et al. J Biotechnol. L-methionine sulfoximine as a novel selection agent for genetic transformation of orchids

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