Free shipping on all orders over $ 500

L-701324

Cat. No. M4956

All AbMole products are for research use only, cannot be used for human consumption.

L-701324 Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 39  USD39 In stock
5mg USD 34  USD34 In stock
10mg USD 56  USD56 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

L-701324 is a potent anticonvulsant compound that reduces the propensity to activate the mesolimbic dopaminergic system in rodents. L-701324 showed beneficial effects in animal models of Parkinson's rigidity, but not in animal models of Parkinson's dyskinesia. L-701324 (2.5-40 mg/kg, I.P.) dose-dependently reduced enhanced muscle tone from haloperidol (1-5 mg/kg, I.P.).

Chemical Information
Molecular Weight 363.79
Formula C21H14ClNO3
CAS Number 142326-59-8
Form Solid
Solubility (25°C) DMSO 36 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ling Liu, et al. Antidepressant-like activity of L-701324 in mice: A behavioral and neurobiological characterization

[2] Nobuhiro Kawai, et al. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus

[3] Christina Zellinger, et al. Pre-treatment with the NMDA receptor glycine-binding site antagonist L-701,324 improves pharmacosensitivity in a mouse kindling model

[4] Kenneth W Perry, et al. Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas

[5] J Konieczny, et al. L-701,324, a selective antagonist at the glycine site of the NMDA receptor, counteracts haloperidol-induced muscle rigidity in rats

Related GluR Products
VU0650786

VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM.

NS-102

NS-102 is a selective kainate (GluK2) receptor antagonist.

VU0424465 

VU0424465 is a potent and partial PAM (positive allosteric modulator)-agonist for mGlu5 mediated iCa2+ mobilization.

ATPA 

ATPA is a selective glutamate receptor GluR5 activator with EC50s of 0.66, 9.5, 1.4, 23, 32, 18, and 14 μM for GluR5wt, GluR5(S741M), GluR5(S721T), GluR5(S721T, S741M), GluR5(S741A), GluR5(S741L), and GluR5(S741V), respectively.

(R)-CPP 

(R)-CPP is a highly potent NMDA receptor antagonist.

  Catalog
Abmole Inhibitor Catalog




Keywords: L-701324 supplier, GluR, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.