L 012 sodium salt is a luminal-based chemiluminescent probe. L 012 sodium salt detects NAPDH oxidase-derived reactive oxygen and nitrogen species (ROS and RNS).
| Molecular Weight | 310.67 |
| Formula | C13H8CIN4NaO2 |
| CAS Number | 143556-24-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 35 mg/mL Water 2 mg/mL (ultrasonic and warming) |
| Storage | 4°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related ROS Products |
|---|
| Dihydroferulic acid
Dihydroferulic acid (Hydroferulic acid) is one of the main metabolites of curcumin and antioxidant/radical-scavenging properties with an IC50 value of 19.5 μM. Dihydroferulic acid (Hydroferulic acid) is a metabolite of human gut microflora as well as a precursor of vanillic acid. |
| Arg-Tyr
Arg-Tyr is a dipeptide which has strong hydroxyl-radical and hydrogen-peroxide scavenging activity. |
| HNGF6A
HNGF6A is a humanin analogue. |
| Glutathione ethyl ester
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. |
| Palmitoyl tripeptide-38
Palmitoyl tripeptide-38 is a bioactive peptide with anti-aging effect . |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
