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KN-93 hydrochloride is a cell-permeable inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMK-II) with a Ki of 370 nM. KN-93 HCl inhibits fibroblast CaMK-II activity and cell growth in a dose-dependent manner, reversibly arrests cells in G1 and induces apoptosis. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations.
| Molecular Weight | 537.5 |
| Formula | C26H30Cl2N2O4S |
| CAS Number | 1956426-56-4 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related CaMK Products |
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| Autocamtide 2
Autocamtide 2 is a highly selective peptide substrate of calcium/calmodulin-dependent protein kinase II (CaMKII). |
| Syntide 2
Syntide 2, a Ca2+- and calmodulin (CaM)-dependent protein kinase II (CaMKII) substrate peptide, selectively inhibits the gibberellin (GA) response, leaving constitutive and abscisic acid-regulated events unaffected. |
| Autocamtide-2-related inhibitory peptide, myristoylated
Autocamtide-2-related inhibitory peptide, myristoylated is the myristoylated Autocamtide-2-related inhibitory peptide. |
| Calmodulin Dependent Protein Kinase Substrate
Calmodulin Dependent Protein Kinase Substrate is a Ca2+- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide. |
| Calmodulin Dependent Protein Kinase Substrate Analog
Calmodulin Dependent Protein Kinase Substrate Analog is a Ca2+- and calmodulin (CaM)-dependent protein kinase (CaMK) substrate peptide. |
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