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KN-92 phosphate

Cat. No. M9254
KN-92 phosphate Structure
Size Price Availability Quantity
10mg USD 330  USD330 In stock
50mg USD 980  USD980 In stock
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Quality Control & Documentation
Biological Activity

KN-92 is an inactive analog of the CaM kinase II inhibitor KN-93. KN-92 is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent kinase II (CaMKII), competitively blocking CaM binding to the kinase (Ki = 370 nM). KN-93 inhibits histamine-induced aminopyrine uptake in parietal cells (IC50 = 300 nM).

Chemical Information
Molecular Weight 554.98
Formula C24H28ClN2O7PS
CAS Number 1135280-28-2
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Rokhlin OW, et al. Cancer Biol Ther. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer.

[2] An P, et al. World J Gastroenterol. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro.

[3] Gao L, et al. Biochem Biophys Res Commun. CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels.

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