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Kira8 (AMG-18) is a single selective IRE1α inhibitor that can allosterically reduce IRE1α RNase activity with an IC50 of 5.9 nM. Kira8 inhibited IRE1α oligomerization and inhibited IRE1α RNase activity against XBP1 and Ins2 RNA. Kira8 reduced ire1 α driven apoptosis in INS-1 cells more effectively than KIRA6 and reversed XBP1 splice promoted by GNF-2[1].
| Molecular Weight | 601.12 |
| Formula | C31H29ClN6O3S |
| CAS Number | 1630086-20-2 |
| Solubility (25°C) | DMSO 60 mg/mL Water 30 mg/mL (ultrasonic and warming and adjust pH to 2 with HCl) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related IRE1 Products |
|---|
| BDM44768
BDM44768 is an inhibitior of IDE. |
| IRE1α kinase-IN-5
IRE1α kinase-IN-5 is a potent IRE1α inhibitor with an Ki of 98 nM. |
| Z4P
Z4P is a BBB-permeable IRE1 inhibitor (IC50: 1.11 μM). |
| IRE1α kinase-IN-9
IRE1α kinase-IN-9 is a potent IRE-1α inhibitor, exhibits an average IC50 value of <0.1 μM. |
| IRE1α kinase-IN-8
IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, is a potent IRE-1α inhibitor. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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