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KDOAM-25 

Cat. No. M29391

All AbMole products are for research use only, cannot be used for human consumption.

KDOAM-25  Structure

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Quality Control & Documentation
Biological Activity

KDOAM-25 is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells.

Chemical Information
Molecular Weight 307.39
Formula C15H25N5O2
CAS Number 2230731-99-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] E N Knyazev, et al. Bull Exp Biol Med. KDM5 Family Demethylase Inhibitor KDOAM-25 Reduces Entry of SARS-CoV-2 Pseudotyped Viral Particles into Cells

[2] Hongjun Zhang, et al. Biomed Res Int. KDOAM-25 Overcomes Resistance to MEK Inhibitors by Targeting KDM5B in Uveal Melanoma

[3] Madlen Merten, et al. Cells. Human Sex Matters: Y-Linked Lysine Demethylase 5D Drives Accelerated Male Craniofacial Osteogenic Differentiation

[4] Anthony Tumber, et al. Cell Chem Biol. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells

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  Catalog
Abmole Inhibitor Catalog




Keywords: KDOAM-25  supplier, Histone demethylase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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