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Juglanin

Cat. No. M14159
Juglanin Structure
Size Price Availability Quantity
5mg USD 1060  USD1060 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Juglanin, a natural occurring flavonoid, is a JNK acticator, with inflammation and anti-tumor activities. Juglanin can induce apoptosis and autophagy on human breast cancer cells.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 418.35
Formula
CAS Number 5041-67-8
Purity >99%
Solubility DMSO 90 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Fangxue Zhang, et al. Juglanin Inhibits Osteoclastogenesis in Ovariectomized Mice via the Suppression of NF-κB Signaling Pathways

[2] Guang Wang, et al. The Inhibitory Effects of Juglanin on Adipogenesis in 3T3-L1 Adipocytes

[3] Jian Zhao, et al. Juglanin suppresses oscillatory shear stress-induced endothelial dysfunction: An implication in atherosclerosis

[4] Ying-Hui Kong, et al. Juglanin administration protects skin against UVB‑induced injury by reducing Nrf2‑dependent ROS generation

[5] Xinxin Chen, et al. Juglanin inhibits IL-1β-induced inflammation in human chondrocytes

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Keywords: Juglanin supplier, JNK, inhibitors

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