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Juglanin

Cat. No. M14159
Juglanin Structure
Size Price Availability Quantity
5mg USD 1060  USD1060 In stock
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Quality Control & Documentation
Biological Activity

Juglanin, a natural occurring flavonoid, is a JNK acticator, with inflammation and anti-tumor activities. Juglanin can induce apoptosis and autophagy on human breast cancer cells.

Chemical Information
Molecular Weight 418.35
CAS Number 5041-67-8
Solubility (25°C) DMSO 90 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Fangxue Zhang, et al. Juglanin Inhibits Osteoclastogenesis in Ovariectomized Mice via the Suppression of NF-κB Signaling Pathways

[2] Guang Wang, et al. The Inhibitory Effects of Juglanin on Adipogenesis in 3T3-L1 Adipocytes

[3] Jian Zhao, et al. Juglanin suppresses oscillatory shear stress-induced endothelial dysfunction: An implication in atherosclerosis

[4] Ying-Hui Kong, et al. Juglanin administration protects skin against UVB‑induced injury by reducing Nrf2‑dependent ROS generation

[5] Xinxin Chen, et al. Juglanin inhibits IL-1β-induced inflammation in human chondrocytes

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Keywords: Juglanin supplier, JNK, inhibitors, activators

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