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JI6 

Cat. No. M30706

All AbMole products are for research use only, cannot be used for human consumption.

JI6  Structure

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Quality Control & Documentation
Biological Activity

JI6 is a potent, selective and orally active FLT3 inhibitor, with IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively. JI6 also inhibits JAK3 and c-Kit, with IC50s of ∼250 and ∼500 nM, respectively. JI6 can be used for the research of acute myeloid leukemia.

Chemical Information
Molecular Weight 383.42
Formula C19H17N3O4S
CAS Number 856436-16-3
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Y Chen, et al. Oncogene. Identification of an orally available compound with potent and broad FLT3 inhibition activity

[2] Jiabing Ji, et al. Anal Biochem. Molecular cloning of large alternative transcripts based on comparative phylogenetic analysis and exploration of an EST database

[3] Jiabing Ji, et al. PLoS One. Restriction site extension PCR: a novel method for high-throughput characterization of tagged DNA fragments and genome walking

[4] Lisa Hale, et al. Biotechniques. An efficient stress-free strategy to displace stable bacterial plasmids

[5] J Theuri, et al. Cytogenet Genome Res. A comparative study of retrotransposons in the centromeric regions of A and B chromosomes of maize

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  Catalog
Abmole Inhibitor Catalog




Keywords: JI6  supplier, FLT3, inhibitors, activators

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