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Jatrorrhizine, an isoquinoline alkaloid found in common medicinal plants, is also a TNIK inhibitor with antibacterial, anti-inflammatory and antitumor activities.
| Molecular Weight | 465.28 |
| Formula | C20H20INO4 |
| CAS Number | 3621-38-3 |
| Form | Solid |
| Storage | 2-8°C |
[3] Janiqua Rolle, et al. J Pharm Pharmacol. Jatrorrhizine: a review of its pharmacological effects
| Related TNIK Products |
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| TNIK-IN-3
TNIK-IN-3 is a potent, selective and orally active TNIK inhibitor with an IC50 value of 0.026 μM. In addition, TNIK-IN-3 inhibits Flt4 (IC50=0.030 μM), Flt1 (IC50=0.191 μM) and DRAK1 (IC50=0.411 μM). -3 can be used in studies related to colorectal cancer. |
| PF-794
PF-794 (PF-06279794) is a potent, selective, ATP-competitive TNIK inhibitor. |
| Mebendazole
Mebendazole is a highly effective, broad-spectrum antihelmintic indicated for the treatment of nematode infestations; has been found as a hedgehog inhibitor. |
| NCB-0846
NCB-0846 is a novel, orally small-molecule Wnt inhibitor that inhibits TNIK (TRAF2 and NCK-Interacting Kinase) with an IC50 value of 21 nM. |
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