About 5 results found for searched term "TNIK" (0.052 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M27826 | Robotnikinin | Hedgehog |
| Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo. | ||
| M42132 | TNIK&MAP4K4-IN-1 | MAPKAPK2/MAP3K/MAP4K |
| TNIK&MAP4K4-IN-1 is a dual inhibitor of TNIK and MAP4K4/HGK with IC50s of 1.29 nM and <10 nM, respectively, in human hepaticstellate cell LX-2. | ||
| M49491 | TNIK-IN-3 | TNIK |
| TNIK-IN-3 is a potent, selective and orally active TNIK inhibitor with an IC50 value of 0.026 μM. In addition, TNIK-IN-3 inhibits Flt4 (IC50=0.030 μM), Flt1 (IC50=0.191 μM) and DRAK1 (IC50=0.411 μM). -3 can be used in studies related to colorectal cancer. | ||
| M55626 | INS018 055 | MAPKAPK2/MAP3K/MAP4K |
| TNIK&MAP4K4-IN-2; INS018_055 | ||
| INS018 055 is a TNIK and MAP4K4 inhibitor with IC50 values of 12-120 nM, respectively. INS018 055 exhibits anti-fibrotic activity across different organs in vivo through oral, inhaled or topical administration. INS018 055 possesses anti-inflammatory effects in addition to its anti-fibrotic profile, validated in multiple in vivo studies. | ||
| M57007 | TNIK-IN-7 | Others |
| TNIK-IN-7 is an inhibitor of Traf2 and Nck-interacting kinase (TNIK), with IC50 of 11 nM, that has antitumor activity. | ||
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