About 12 results found for searched term "TNIK" (0.132 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M27826 | Robotnikinin | Hedgehog |
| Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo. | ||
| M42132 | TNIK&MAP4K4-IN-1 | MAPKAPK2/MAP3K/MAP4K |
| TNIK&MAP4K4-IN-1 is a dual inhibitor of TNIK and MAP4K4/HGK with IC50s of 1.29 nM and <10 nM, respectively, in human hepaticstellate cell LX-2. | ||
| M49491 | TNIK-IN-3 | TNIK |
| TNIK-IN-3 is a potent, selective and orally active TNIK inhibitor with an IC50 value of 0.026 μM. In addition, TNIK-IN-3 inhibits Flt4 (IC50=0.030 μM), Flt1 (IC50=0.191 μM) and DRAK1 (IC50=0.411 μM). -3 can be used in studies related to colorectal cancer. | ||
| M5279 | NCB-0846 | TNIK |
| NCB-0846 is a novel, orally small-molecule Wnt inhibitor that inhibits TNIK (TRAF2 and NCK-Interacting Kinase) with an IC50 value of 21 nM. | ||
| M8556 | KY-05009 | Others |
| KY-05009 is a Traf2- and Nck-interacting kinase (TNIK) inhibitor that inhibits the epithelial-to-mesenchymal transition (EMT) in cancer cells. | ||
| M16102 | Jatrorrhizine | TNIK |
| Jatrorrhizine, an isoquinoline alkaloid found in common medicinal plants, is also a TNIK inhibitor with antibacterial, anti-inflammatory and antitumor activities. | ||
| M16830 | Orobol | Casein Kinase |
| Orobol is a major soy isoflavone that inhibits CK1ε, VEGFR2, MAP4K5, MNK1, MUSK, TOPK, and TNIK (IC50=1.24-4.45 μM), as well as PI3K isoforms (IC50=3.46-5.27 μM for PI3K α/β/γ/K/δ). | ||
| M20713 | DMX-5084 | MAPKAPK2/MAP3K/MAP4K |
| DMX-5804 is a potent, orally active and selective inhibitor of Mitogen-activated protein kinase kinase kinase kinase-4 (MAP4K4) with IC50 of 3 nM for human MAP4K4. DMX-5804 is more potent on human MAP4K4 with pIC50 of 8.55 than MINK1/MAP4K6 and TNIK/MAP4K7 with pIC50 of 8.18 and 7.96, respectively. | ||
| M25032 | Docaravimab | Anti-infection |
| Docaravimab is an antibody, targeting ERA (Evelyn-Rockitniki-Abelseth) glycoprotein ectodomain epitope G-III. Docaravimab can be used in research of Rabies. | ||
| M31148 | PF-794 | TNIK |
| PF-06279794 | ||
| PF-794 (PF-06279794) is a potent, selective, ATP-competitive TNIK inhibitor. | ||
| M42941 | TINK-IN-1 | Others |
| TINK-IN-1 is a potent and selective Traf2- and Nck-interacting kinase (TNIK) inhibitor with an IC50 of 8 nM. | ||
| M45316 | ON 108600 | Casein Kinase |
| ON 108600 is an inhibitor of CK2 (Casein Kinase2)/TNIK/DYRK1 with IC50 values of 0.016 μm/0.007 μM, 0.028 μM, 0.05 μM/0.005 μM, and 0.005 μM for DYRK1A/DYRKB, DYRK2, CK2α1/CK2α2, and TNIK, respectively. 0.005 μM. It has anti-tumor activity. | ||
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