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Robotnikinin 

Cat. No. M27826

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Robotnikinin  Structure
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Biological Activity

Robotnikinin is a small molecule capable of binding to and inhibiting the activity of Sonic Hedgehog (Shh) signaling up stream of Smo.

Robotnikinin (50 µM) prevents the ShhN-induced LC3-II increase. Robotnikinin (5 μM) downregulates classical NF-κB pathway proteins in H929 and U266 cell lines cocultured with HS-5 cells, suggesting a link between Hh signaling and the NF-κB pathway in MM.

Chemical Information
Molecular Weight 454.95
Formula C25H27ClN2O4
CAS Number 1132653-79-2
Solubility (25°C) DMSO 20 mg/mL
Storage 4°C, protect from light, sealed
References

[1] Manuel Hitzenberger, et al. Front Chem. The Binding Mode of the Sonic Hedgehog Inhibitor Robotnikinin, a Combined Docking and QM/MM MD Study

[2] Chris Dockendorff, et al. ACS Med Chem Lett. Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies

[3] Nadia B Hassounah, et al. Clin Cancer Res. Molecular pathways: the role of primary cilia in cancer progression and therapeutics with a focus on Hedgehog signaling

[4] Swan Hwang, et al. J Bioinform Comput Biol. Discovery and evaluation of potential sonic hedgehog signaling pathway inhibitors using pharmacophore modeling and molecular dynamics simulations

[5] Benjamin Z Stanton, et al. Mol Biosyst. Small-molecule modulators of the Sonic Hedgehog signaling pathway

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Keywords: Robotnikinin  supplier, Hedgehog, inhibitors, activators

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