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IST5-002

Cat. No. M28215

All AbMole products are for research use only, cannot be used for human consumption.

IST5-002 Structure
Synonym:

N6-Benzyladenosine-5'-phosphate

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Quality Control & Documentation
Biological Activity

IST5-002, a potent Stat5a/b inhibitor, selectively inhibits transcriptional activity of Stat5a/b (IC50s: 1.5 μM for Stat5a, 3.5 μM for Stat5b). IST5-002 inducs cell apoptotic and death of prostate cancer cells and chronic myeloid leukemia (CML) cells. IST5-002 can be used in the research of prostate cancer and chronic myeloid leukemia (CML).

Chemical Information
Molecular Weight 437.34
Formula C17H20N5O7P
CAS Number 13484-66-7
Form Solid
Solubility (25°C) Water 125 mg/mL (ultrasonic)
DMSO 125 mg/mL (ultrasonic)
Storage Powder -20°C
References

[1] Cristina Maranto, et al. Cancers (Basel). Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo

[2] Kai Huang, et al. Ann Palliat Med. The anti-CXCL4 antibody depletes CD4(+)CD25(+)FOXP3(+) regulatory T cells in CD4+ T cells from chronic osteomyelitis patients by the STAT5 pathway

[3] Zhiyong Liao, et al. Mol Cancer Ther. Structure-Based Screen Identifies a Potent Small Molecule Inhibitor of Stat5a/b with Therapeutic Potential for Prostate Cancer and Chronic Myeloid Leukemia

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Keywords: IST5-002, N6-Benzyladenosine-5'-phosphate supplier, STAT, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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