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Ispronicline

Cat. No. M29693

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Ispronicline Structure
Synonym:

TC-1734; ACD3480

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Quality Control & Documentation
Biological Activity

Ispronicline (TC-1734), an orally active, brain-selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist, has shown memory-enhancing properties in rodents and a good tolerability profile. Ispronicline binds to the α4β2 nAChR with high affinity (Ki=11 nM) and is highly selective to other nAChRs such as α7 nAChR and α3β4 nAChR.

Chemical Information
Molecular Weight 234.34
Formula C14H22N2O
CAS Number 252870-53-4
Form Liquid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Gail Winger. Behav Pharmacol. Nicotine-like discriminative and aversive effects of two α4β2-selective nicotine agonists, ispronicline and metanicotine

[2] Massimiliano Buoli, et al. Expert Rev Neurother. Alternative pharmacological strategies for adult ADHD treatment: a systematic review

[3] Geoffrey C Dunbar, et al. J Psychopharmacol. Effect of ispronicline, a neuronal nicotinic acetylcholine receptor partial agonist, in subjects with age associated memory impairment (AAMI)

[4] Patrick Lippiello, et al. J Mol Neurosci. Ispronicline: a novel alpha4beta2 nicotinic acetylcholine receptor-selective agonist with cognition-enhancing and neuroprotective properties

[5] Hugo Geerts. Curr Opin Investig Drugs. Ispronicline (Targacept)

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Keywords: Ispronicline, TC-1734; ACD3480 supplier, AChR/AChE, inhibitors, activators

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