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Isochavicine

Cat. No. M43750
Isochavicine Structure
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Biological Activity

Isochavicine is an alkaloids that can be isolated from Piper retrofractum.

Chemical Information
Molecular Weight 285.34
Formula C17H19NO3
CAS Number 30511-77-4
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Toshiyuki Mizumoto et al. Shokuhin Eiseigaku Zasshi. [Quantitative Analysis of Piperine and the Derivatives in Long Pepper Extract by HPLC Using Relative Molar Sensitivity]

[2] Foroogh Namjoyan et al. Jundishapur J Nat Pharm Prod. Evaluation of drying process on the composition of black pepper ethanolic extract by high performance liquid chromatography with diode array detector

[3] Shakti Sahi et al. J Mol Model. Leishmania donovani pteridine reductase 1: comparative protein modeling and protein-ligand interaction studies of the leishmanicidal constituents isolated from the fruits of Piper longum

[4] Yukiko Okumura et al. Biosci Biotechnol Biochem. Activation of TRPV1 and TRPA1 by black pepper components

[5] Nobuyuki Kozukue et al. J Agric Food Chem. Kinetics of light-induced cis-trans isomerization of four piperines and their levels in ground black peppers as determined by HPLC and LC/MS

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