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Iristectorigenin B

Cat. No. M10621
Iristectorigenin B Structure
Size Price Availability Quantity
5mg USD 450  USD450 In stock
10mg USD 600  USD600 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Iristectorigenin B is a liver X receptor (LXR) modulator, which stimulates the transcriptional activity of both LXR-α and LXR-β.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 330.29
Formula C17H14O7
CAS Number 86849-77-6
Purity >98%
Solubility DMSO
Storage at -20°C
References

[1] Olha Mykhailenko, et al. Molecules. Pharmacological Potential and Chemical Composition of Crocus sativus Leaf Extracts

[2] Jie Liu, et al. Xenobiotica. Identification of the metabolites produced following Iris tectorum Maxim oral administration and a network pharmacology-based analysis of their potential pharmacological properties

[3] Hyun Lim, et al. Arch Pharm Res. Methyl caffeate and some plant constituents inhibit age-related inflammation: effects on senescence-associated secretory phenotype (SASP) formation

[4] Le Zhang, et al. J Ethnopharmacol. Belamcanda chinensis (L.) DC-An ethnopharmacological, phytochemical and pharmacological review

[5] Hee-jin Jun, et al. Biotechnol Lett. Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells

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Keywords: Iristectorigenin B supplier, Liver X Receptor, inhibitors

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