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Iristectorigenin B

Cat. No. M10621
Iristectorigenin B Structure
Size Price Availability Quantity
5mg USD 450  USD450 In stock
10mg USD 600  USD600 In stock
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Quality Control & Documentation
Biological Activity

Iristectorigenin B is a liver X receptor (LXR) modulator, which stimulates the transcriptional activity of both LXR-α and LXR-β.

Chemical Information
Molecular Weight 330.29
Formula C17H14O7
CAS Number 86849-77-6
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Olha Mykhailenko, et al. Molecules. Pharmacological Potential and Chemical Composition of Crocus sativus Leaf Extracts

[2] Jie Liu, et al. Xenobiotica. Identification of the metabolites produced following Iris tectorum Maxim oral administration and a network pharmacology-based analysis of their potential pharmacological properties

[3] Hyun Lim, et al. Arch Pharm Res. Methyl caffeate and some plant constituents inhibit age-related inflammation: effects on senescence-associated secretory phenotype (SASP) formation

[4] Le Zhang, et al. J Ethnopharmacol. Belamcanda chinensis (L.) DC-An ethnopharmacological, phytochemical and pharmacological review

[5] Hee-jin Jun, et al. Biotechnol Lett. Iristectorigenin B isolated from Belamcanda chinensis is a liver X receptor modulator that increases ABCA1 and ABCG1 expression in macrophage RAW 264.7 cells

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Keywords: Iristectorigenin B supplier, Liver X Receptor, inhibitors, activators


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