Free shipping on all orders over $ 500


Cat. No. M14603
Indole-3-carbinol Structure

I3C; 3-Indolemethanol

Size Price Availability Quantity
200mg USD 50  USD50 In stock
1g USD 70  USD70 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Indole-3-carbinol (I3C) inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).

Chemical Information
Molecular Weight 147.17
CAS Number 700-06-1
Solubility (25°C) DMSO 90 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Barbara Licznerska, et al. Indole-3-Carbinol and Its Role in Chronic Diseases

[2] Bryant W Megna, et al. Indole-3-carbinol induces tumor cell death: function follows form

[3] Si-qi Wang, et al. Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection

[4] No authors listed. Indole-3-carbinol. Monograph

[5] M N Preobrazhenskaya, et al. Indole-3-carbinol

Related NF-κB Products

B022 is a potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 4.2 nM and IC50 of 15.1 nM. B022 protects liver from toxin-induced inflammation, oxidative stress and injury.


SN52 is a novel potent, competitive, and cell-permeable inhibitor of nuclear factor-kappaB (NF-κB). SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation of p52-RelB heterodimers. SN52 has a strong radiosensitization effect on prostate cancer cells.


CDDO-dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound that effectively activates Nrf2 and inhibits the pro-inflammatory transcription factor NF-κB.


CORM-3 is a carbon monoxide-releasing molecule that attenuates nuclear ectopic NF-κB p65, reduces ROS production, and increases intracellular glutathione and superoxide dismutase levels.CORM-3 reduces the activation of NLRP3 inflammatory vesicles.


INH14 is an inhibitor of TLR2-mediated NF-kB activation with IC50 values of 8.975 μM and 3.598 μM for IKKα and IKKβ, respectively.

Abmole Inhibitor Catalog

Keywords: Indole-3-carbinol, I3C; 3-Indolemethanol supplier, NF-κB, inhibitors, activators

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.