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Indimitecan

Cat. No. M30893

All AbMole products are for research use only, cannot be used for human consumption.

Indimitecan Structure

Synonym:

LMP776

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation

Purity: ≥99.0%
COA
MSDS

Product Information

Biological Activity

Indimitecan (LMP776) is a topoisomerase I (Top1) inhibitor with anticancer activities.

Chemical Information

Molecular Weight	459.45
Formula	C25H21N3O6
CAS Number	915360-05-3
Form	Solid
Solubility (25°C)	DMSO 8.33 mg/mL (ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

References

[1] Florence Coussy, et al. Sci Transl Med. BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers

[2] Anish Thomas, et al. Clin Cancer Res. Targeting Topoisomerase I in the Era of Precision Medicine

[3] Jenna H Burton, et al. Clin Cancer Res. NCI Comparative Oncology Program Testing of Non-Camptothecin Indenoisoquinoline Topoisomerase I Inhibitors in Naturally Occurring Canine Lymphoma

[4] Daniel E Beck, et al. J Med Chem. Synthesis and biological evaluation of new carbohydrate-substituted indenoisoquinoline topoisomerase I inhibitors and improved syntheses of the experimental anticancer agents indotecan (LMP400) and indimitecan (LMP776)

[5] Maris A Cinelli, et al. J Med Chem. Identification, synthesis, and biological evaluation of metabolites of the experimental cancer treatment drugs indotecan (LMP400) and indimitecan (LMP776) and investigation of isomerically hydroxylated indenoisoquinoline analogues as topoisomerase I poiso䲧

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Catalog

Abmole Inhibitor Catalog

Keywords: Indimitecan, LMP776 supplier, Topoisomerase, inhibitors, activators

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