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Inavolisib

Cat. No. M11405
Inavolisib Structure
Synonym:

GDC-0077; RG6114;RO-7113755

Size Price Availability Quantity
5mg USD 540  USD540 In stock
10mg USD 880  USD880 In stock
25mg USD 1240  USD1240 In stock
50mg USD 1900  USD1900 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Gdc-0077 (RG6114) is an effective, oral, selective PI3Kα inhibitor (IC50=0.038 nM). Gdc-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting phosphorylation of PIP2 to PIP3. Compared with wild-type PI3Kα, GDC-0077 (RG6114) showed higher selectivity against mutants.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 407.37
Formula C18H19F2N5O4
CAS Number 2060571-02-8
Purity >98%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
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Keywords: Inavolisib, GDC-0077; RG6114;RO-7113755 supplier, PI3K, inhibitors

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