About 1 result found for searched term "Inavolisib" (0.36 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M11405 | Inavolisib (GDC-0077) | PI3K |
| GDC-0077; RG6114；RO-7113755 | ||
| Inavolisib (GDC-0077; RG6114) is a potential best-in-class, orally selective PI3Kα inhibitor (IC50=0.038 nM). GDC-0077 (RG6114) exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. GDC-0077 (RG6114) is more selective for mutants compared to wild-type PI3Kα. It can trigger the degradation of mutation-producing PIK3α. | ||
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