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IITZ-01

Cat. No. M20643

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IITZ-01 Structure
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Biological Activity

IITZ-01 is a potent autophagy inhibitor, enhancing autophagosome accumulation but inhibiting autophagosomal degradation by impairing lysosomal function.

Chemical Information
Molecular Weight 482.51
Formula C26H23FN8O
CAS Number 1807988-47-1
Solubility (25°C) DMSO 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Sk Abrar Shahriyar, et al. Cancers (Basel). Upregulation of DR5 and Downregulation of Survivin by IITZ-01, Lysosomotropic Autophagy Inhibitor, Potentiates TRAIL-Mediated Apoptosis in Renal Cancer Cells via Ubiquitin-Proteasome Pathway

[2] Lalita Guntuku, et al. Oncogene. IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo

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Keywords: IITZ-01 supplier, Autophagy, inhibitors, activators

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