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Ifetroban (BMS-180291) is a potent and selective thromboxane receptor antagonist. The IC50 for inhibition of arachadonate or U-46619-induced platelet aggregation in human plasma is 7 nM and 30 nM, respectively. Ifetroban inhibits platelet aggregation in African green monkey 100% at 3 mpk, and blocks the contractile effects of U-46619 and Ang II in rabbit renal afferent arterioles.
| Molecular Weight | 462.51 |
| Formula | C25H31N2O5 · Na |
| CAS Number | 156715-37-6 |
| Solubility (25°C) | Water: 20 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] L Rosenfeld, et al. Ifetroban sodium: an effective TxA2/PGH2 receptor antagonist
[2] L Raij, et al. Cigarette smoke-induced endothelium dysfunction: role of superoxide anion
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