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Ianalumab

Cat. No. M24854

All AbMole products are for research use only, cannot be used for human consumption.

Ianalumab Structure
Synonym:

VAY-736

Price and Availability

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Quality Control & Documentation
Biological Activity

Ianalumab (VAY-736) is a humanized, decarboxylated antibody against BAFF-R. Ianalumab can block the interaction between BAFF and BAFF-R and antagonize the apoptosis protection mediated by BAFF. Ianalumab exerts antibody-dependent cytotoxic (ADCC), depending on effector cell activation mediated by immune receptor tyrosine activation motif (ITAM).

Chemical Information
CAS Number 1929549-92-7
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Sarah Dyball, et al. Lancet. Ianalumab in Sjögren's syndrome: what can we learn from lupus trials?

[2] Albert J Czaja. Dig Dis Sci. Advancing Biologic Therapy for Refractory Autoimmune Hepatitis

[3] Simon J Bowman, et al. Lancet. Safety and efficacy of subcutaneous ianalumab (VAY736) in patients with primary Sjögren's syndrome: a randomised, double-blind, placebo-controlled, phase 2b dose-finding trial

[4] Clio P Mavragani, et al. J Autoimmun. Sjögren's syndrome: Old and new therapeutic targets

[5] Thomas Dörner, et al. Ann Rheum Dis. Treatment of primary Sjögren's syndrome with ianalumab (VAY736) targeting B cells by BAFF receptor blockade coupled with enhanced, antibody-dependent cellular cytotoxicity

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Keywords: Ianalumab, VAY-736 supplier, inhibitors, activators

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