Free shipping on all orders over $ 500

HJC0152

Cat. No. M20625
HJC0152 Structure
Size Price Availability
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor with remarkably improved aqueous solubility.

Chemical Information
Molecular Weight 406.65
Formula C15H14Cl3N3O4
CAS Number 1420290-99-8
Solubility (25°C) DMSO 88 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Malik Bisserier, et al. Int J Mol Sci. Combination Therapy with STAT3 Inhibitor Enhances SERCA2a-Induced BMPR2 Expression and Inhibits Pulmonary Arterial Hypertension

[2] Lu Lu, et al. Cell Prolif. HJC0152 suppresses human non-small-cell lung cancer by inhibiting STAT3 and modulating metabolism

[3] Zhaoqing Li, et al. Am J Cancer Res. A novel STAT3 inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma

[4] Xiaoxia Jiang, et al. Cancer Manag Res. HJC0152, a novel STAT3 inhibitor with promising anti-tumor effect in gastric cancer

[5] Yu Wang, et al. Mol Cancer Ther. Suppression of the Growth and Invasion of Human Head and Neck Squamous Cell Carcinomas via Regulating STAT3 Signaling and the miR-21/β-catenin Axis with HJC0152

Related STAT Products
STAT3-IN-21, cell-permeable, negative control

STAT3-IN-21, cell-permeable, negative control, a peptide, is a negative control for Stat3 activity detection.

STAT3-IN-24, cell-permeable

STAT3-IN-24, cell-permeable (PpYLKTK-mts) is a STAT3 peptide inhibitor.

5-FAM-GpYLPQTV-NH2

5-FAM-GpYLPQTV-NH2 is a fluorescently labeled peptide and has STAT3 inhibitory activity.

Ac-GpYLPQTV-NH2

Ac-GpYLPQTV-NH2 is a STAT3 inhibitor with an IC50 value of 0.33 μM.

XZH-5

XZH-5 inhibits the phosphorylation of STAT3 and results in the induction of apoptosis and reduction of colony forming ability.

  Catalog
Abmole Inhibitor Catalog




Keywords: HJC0152 supplier, STAT, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.