HCGRP-(8-37) is a human calcitonin gene-related peptide (hCGRP) fragment and also an antagonist of CGRP receptor.
|Solubility (25°C)||Water ≥ 20 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related CGRP Receptor Products|
Rimegepant Sulfate is a potent, selective, competitive, orally active calcitonin gene-related peptide (CGRP) antagonist with a Ki of 0.027 nM.May be used in migraine-related studies.
Calcitonin (human) is a calcitonin that lowers blood calcium levels and inhibits bone resorption and may be used in studies related to hypercalcemia or osteoporosis.
Cagrilintide acetate is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity.
Vazegepant is the first intranasal CGRP receptor antagonist for the study the acute research of migraine.
|α-CGRP, human TFA
α-CGRP, human TFA is a regulatory neuropeptide of 37 amino acids. α-CGRP, human TFA can be used as a potent vasodilator.
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