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Cat. No. M13932
HCGRP-(8-37) Structure

Human α-CGRP (8-37)

Size Price Availability Quantity
1mg USD 340  USD340 In stock
5mg USD 1100  USD1100 In stock
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Quality Control & Documentation
Biological Activity

HCGRP-(8-37) is a human calcitonin gene-related peptide (hCGRP) fragment and also an antagonist of CGRP receptor.

Chemical Information
Molecular Weight 3125.59
CAS Number 119911-68-1
Solubility (25°C) Water ≥ 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] J Rinder, et al. Effects of hCGRP 8-37 and the NK1-receptor antagonist SR 140.333 on capsaicin-evoked vasodilation in the pig nasal mucosa in vivo

[2] Y Boulanger, et al. Structure of human calcitonin gene-related peptide (hCGRP) and of its antagonist hCGRP 8-37 as determined by NMR and molecular modeling

[3] L Bartho, et al. Studies on the mechanism of the contractile action of rat calcitonin gene-related peptide and of capsaicin on the guinea-pig ileum: effect of hCGRP (8-37) and CGRP tachyphylaxis

[4] T Chiba, et al. Calcitonin gene-related peptide receptor antagonist human CGRP-(8-37)

[5] C A Maggi, et al. Human alpha-calcitonin gene-related peptide-(8-37) as an antagonist of exogenous and endogenous calcitonin gene-related peptide

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Keywords: HCGRP-(8-37), Human α-CGRP (8-37) supplier, CGRP Receptor, inhibitors, activators

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