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H3B-6527

Cat. No. M5242

All AbMole products are for research use only, cannot be used for human consumption.

H3B-6527 Structure

Size	Price	Availability	Quantity
1mg	USD 80 USD80	In stock
5mg	USD 220 USD220	In stock
10mg	USD 360 USD360	In stock

Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation

Purity: 99.13%
COA
MSDS
H-NMR
LC/MS

Product Information

Biological Activity

H3B-6527 (H3 Biomedicine) is a highly selective FGFR4 inhibitor with potent antitumour activity in FGF19 amplified cell lines and mice.

Chemical Information

Molecular Weight	629.54
Formula	C29H34Cl2N8O4
CAS Number	1702259-66-2
Solubility (25°C)	≥ 6.3 mg/mL in DMSO
Storage	Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month

References

[1] Robert Roskoski Jr. The role of fibroblast growth factor receptor (FGFR) protein-tyrosine kinase inhibitors in the treatment of cancers including those of the urinary bladder

[2] F Colombo, et al. Correlation of the in vitro biotransformation of H3B-6527 in dog and human hepatocytes with the in vivo metabolic profile of 14 C-H3B-6527 in a dog mass balance study

[3] Liwei Lang, et al. Fibroblast Growth Factor Receptor 4 Targeting in Cancer: New Insights into Mechanisms and Therapeutic Strategies

[4] Nathalie Rioux, et al. Effect of a high-fat meal on the relative bioavailability of H3B-6527, a novel FGFR4 inhibitor, in healthy volunteers

[5] Jaya Julie Joshi, et al. H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma

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Catalog

Abmole Inhibitor Catalog

Keywords: H3B-6527 supplier, FGFR, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.

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