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H-7

Cat. No. M7861
H-7 Structure
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Biological Activity

Inhibitor of cyclic nucleotide dependent protein kinase (PKA) and protein kinase C.

Chemical Information
Molecular Weight 291.37
Formula C14H17N3O2S
CAS Number 84477-87-2
Solubility (25°C) ethanol: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xi-Meng Chen, et al. Improved Methods for the Synthesis of KB 3 H 8, NH 3 B 3 H 7, and N-Alkyl Analogues of NH 3 B 3 H 7

[2] Aleksei V Golubev, et al. Synthesis of Perchlorinated Sulfonium Derivatives of closo-Decaborate Anion [2-B 10 Cl 9 SR 2] - (R = i-C 3 H 7, n-C 3 H 7, n-C 4 H 9, n-C 8 H 17, n-C 12 H 25, n-C 18 H 37, CH 2 Ph, and cyclo-S(CH 2) 4)

[3] Danijela Apostolovic, et al. Purification and Initial Characterization of Ara h 7, a Peanut Allergen from the 2S Albumin Protein Family

[4] Neil J Reilly, et al. Gas-Phase Optical Detection of 3-Ethynylcyclopentenyl: A Resonance-Stabilized C 7 H 7 Radical with an Embedded 1-Vinylpropargyl Chromophore

[5] Anna M Ehlers, et al. Ara h 7 isoforms share many linear epitopes: Are 3D epitopes crucial to elucidate divergent abilities?

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Keywords: H-7 supplier, inhibitors, activators

 
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