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H-151 is a highly potent, selective and covalent antagonist of STING, reduces TBK1 phosphorylation and suppresses human STING palmitoylation. H-151 (0.02-2 μM) reduces IFNβ luciferase reporter measurements of HEK293T cells. H-151 (0.5 μM; 2 h) inhibits the phosphorylation of TBK1 in THP-1 cells.
| Molecular Weight | 279.34 |
| Formula | C17H17N3O |
| CAS Number | 941987-60-6 |
| Solubility (25°C) | DMSO ≥ 100 mg/mL |
| Storage | -20°C, dry, sealed |
[2] Simone M Haag, et al. Nature. Targeting STING with covalent small-molecule inhibitors
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