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Gyki-52466 is a 2, 3-bendiazepine compound. As an ionic glutamate receptor antagonist, gyki-52466 is a non-competitive AMPA receptor antagonist (IC50 values of AMPA-, Kainate - and NMDA induced responses are 10-20, ~450 and >>50 μM, respectively). Oral active anticonvulsant compounds and skeletal muscle relaxation compounds. Unlike conventional 4, 5-benzodiazepines, Gyki-52466 and related 2, 3-benzodiazepines do not act on gabA-A receptors. Like other AMPA receptor antagonists, GYki-52466 has anticonvulsant and neuroprotective properties.
| Molecular Weight | 293.32 |
| Formula | C17H15N3O2 |
| CAS Number | 102771-26-6 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related GluR Products |
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| VU0650786
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| NS-102
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| VU0424465
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| ATPA
ATPA is a selective glutamate receptor GluR5 activator with EC50s of 0.66, 9.5, 1.4, 23, 32, 18, and 14 μM for GluR5wt, GluR5(S741M), GluR5(S721T), GluR5(S721T, S741M), GluR5(S741A), GluR5(S741L), and GluR5(S741V), respectively. |
| (R)-CPP
(R)-CPP is a highly potent NMDA receptor antagonist. |
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