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GW-870086 is a glucocorticoid receptor agonist, with pIC50 of 10.1 in A549 cells expressing NF-κB. GW-870086 (1 pM-1 μM) dose-dependently inhibits the L-6 release induced by TNF-α in A549 epithelial carcinoma cells and by IL-1 in MG63 osteosarcoma cells (pIC50s, 9.6, 10.2). GW-870086 (10-100 nM) significantly increases fibronectin secretion.
| Molecular Weight | 559.64 |
| Formula | C31H39F2NO6 |
| CAS Number | 827319-43-7 |
| Solubility (25°C) | DMSO ≥ 10 mM |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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