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GNE684 

Cat. No. M29640

All AbMole products are for research use only, cannot be used for human consumption.

GNE684  Structure

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Quality Control & Documentation
Biological Activity

GNE684 is an orally active, potent receptor-interacting protein 1 (RIP1) inhibitor with Kiapp values of 21 nM, 189 nM, and 691 nM for human, mouse, and rat RIP1, respectively, and can be used in studies related to acute graft-versus-host disease (aGVHD).

Chemical Information
Molecular Weight 432.48
Formula C23H24N6O3
CAS Number 2438637-64-8
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Matthias Kist, et al. Cell Death Differ. Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death

[2] Joshua D Webster, et al. J Leukoc Biol. RIP1 kinase activity is critical for skin inflammation but not for viral propagation

[3] Snahel Patel, et al. Cell Death Differ. RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

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  Catalog
Abmole Inhibitor Catalog




Keywords: GNE684  supplier, RIPK, inhibitors, activators

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