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GL3

Cat. No. M19462
GL3 Structure
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Biological Activity

GL3, the major component of O. fragrans seeds, is a derivative based on both phenylethanoid and methyloleoside.

Chemical Information
Molecular Weight 1073.01
Formula C48H64O27
CAS Number 60037-39-0
Form Solid
Solubility (25°C) DMSO 100 mg/mL (ultrasonic)
Storage 4°C, protect from light
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yuping Qiu, et al. Proc Natl Acad Sci U S A. EIN3 and RSL4 interfere with an MYB-bHLH-WD40 complex to mediate ethylene-induced ectopic root hair formation in Arabidopsis

[2] Xiao-Chen Wang, et al. Plant J. Arabidopsis MYB4 plays dual roles in flavonoid biosynthesis

[3] Emma H McCafferty, et al. Drugs. Migalastat: A Review in Fabry Disease

[4] Duo Xia, et al. Mol Plant. GL3.3, a Novel QTL Encoding a GSK3/SHAGGY-like Kinase, Epistatically Interacts with GS3 to Produce Extra-long Grains in Rice

[5] Syed Rizwan A. Bokhari, et al. Fabry Disease

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