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FT827

Cat. No. M10818

All AbMole products are for research use only, cannot be used for human consumption.

FT827  Structure

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Quality Control & Documentation
Biological Activity

FT827 is a selective and covalent ubiquitin-specific protease 7 (USP7) inhibitor (Ki=4.2 µM). FT827 binds to the USP7 catalytic domain (USP7CD; residues 208-560) with an apparent Kd value of 7.8 µM.

Chemical Information
Molecular Weight 548.61
Formula C27H28N6O5S
CAS Number 1959537-86-0
Solubility (25°C) DMSO ≥ 100 mg/mL
Storage Powder -20°C, sealed
References

[1] Andrew P Turnbull, et al. Nature. Molecular basis of USP7 inhibition by selective small-molecule inhibitors

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XL177A is a highly potent and selective irreversible USP7 inhibitor with an IC50 of 0.34 nM.

LDN-91946 

LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a Ki app of 2.8 μM.

USP5-IN-1 

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  Catalog
Abmole Inhibitor Catalog




Keywords: FT827 supplier, Deubiquitinase, inhibitors, activators

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